NMR Spectroscopy Now Available within SPDo you want to confirm the structure of your molecule, identify impurities or assay the strength of your material in a straight forward way?
Two NMR (Nuclear Magnetic Resonance) instruments will be placed at SP Process Development in Södertälje. Currently a 500MHz system is up and running and a 600MHz system which will be installed later this year. The instruments are equipped to detect many different nuclei, e.g., 1H, 2H, 3H, 11B, 13C, 15N, 19F, 31P and several more in the broad band range. At the moment we offer experiments for solution state NMR.
In organic chemistry, NMR is mainly used for the determination of molecular structure or for the study of the dynamics of a molecular system. NMR is a very sensitive tool to variations in molecular structure. As can be seen below, NMR spectroscopy can be used to determine which molecule you have out of several possible candidates.
NMR spectroscopy utilizes the fact that some atomic nuclei possess a nuclear spin not equal to zero. When such a sample is inserted into a magnetic field (the NMR magnet) it acts somewhat like a bar magnet and orients with the field. If you expose the oriented nuclei to radiofrequency pulses (generated by the spectrometer console) you will be able to gain information about the magnetic and chemical environment of the studied nuclei. This information is translated into, e.g., structure, variations in structure over time, mobility of a system, mobility within a system (diffusion) and much more by the experiences NMR specialist.
Figure 1. Every organic molecule has its unique NMR spectrum.
Here, a 1H NMR spectrum shows which out of four possible structures is correct.
Figure 2. SP Process Development’s 500 MHZ NMR System, showing the magnet to the right and the spectrometer console to the left.